Section outline

  • Paper discussions will include description of figure panels included in the article by the students, who will be called by the class lead to provide context, describe the results in each figure, discuss the interpretation and implications of the results, suggest additional experiments or controls that would expand the implications of the results, and criticize the methodology, presentation, and description of the results in the paper. The main goal of this activity is to “act as peer-reviewers” and train critical thinking.

    We will discuss the following paper: 
    Bolton KL, Ptashkin RN, Gao T, Braunstein L, Devlin SM, Kelly D, Patel M, Berthon A, Syed A, Yabe M, Coombs CC, Caltabellotta NM, Walsh M, Offit K, Stadler Z, Mandelker D, Schulman J, Patel A, Philip J, Bernard E, Gundem G, Ossa JEA, Levine M, Martinez JSM, Farnoud N, Glodzik D, Li S, Robson ME, Lee C, Pharoah PDP, Stopsack KH, Spitzer B, Mantha S, Fagin J, Boucai L, Gibson CJ, Ebert BL, Young AL, Druley T, Takahashi K, Gillis N, Ball M, Padron E, Hyman DM, Baselga J, Norton L, Gardos S, Klimek VM, Scher H, Bajorin D, Paraiso E, Benayed R, Arcila ME, Ladanyi M, Solit DB, Berger MF, Tallman M, Garcia-Closas M, Chatterjee N, Diaz LA Jr, Levine RL, Morton LM, Zehir A, Papaemmanuil E. Cancer therapy shapes the fitness landscape of clonal hematopoiesis. Nat Genet. 2020 Nov;52(11):1219-1226. doi: 10.1038/s41588-020-00710-0. Epub 2020 Oct 26. PMID: 33106634; PMCID: PMC7891089.



    Additionally, to help to introduce the topic of Precision Medicine (Cancer Genomics and Lung Cancer) , Breast Cancer, and Cancer Metastasis we are providing a series of recorded lectures from GSK. These lectures should be watched before the class. If you have any questions from these lectures, please, bring them to the in person class.