Section outline

  • Paper discussions will include description of figure panels included in the article by the students, who will be called by the class lead to provide context, describe the results in each figure, discuss the interpretation and implications of the results, suggest additional experiments or controls that would expand the implications of the results, and criticize the methodology, presentation, and description of the results in the paper. The main goal of this activity is to “act as peer-reviewers” and train critical thinking.

    We will discuss the following paper: 

    Chia SB, Johnson BJ, Hu J, Valença-Pereira F, Chadeau-Hyam M, Guntoro F, Montgomery H, Boorgula MP, Sreekanth V, Goodspeed A, Davenport B, De Dominici M, Zaberezhnyy V, Schleicher WE, Gao D, Cadar AN, Petriz-Otaño L, Papanicolaou M, Beheshti A, Baylin SB, Guarnieri JW, Wallace DC, Costello JC, Bartley JM, Morrison TE, Vermeulen R, Aguirre-Ghiso JA, Rincon M, DeGregori J. Respiratory viral infections awaken metastatic breast cancer cells in lungs. Nature. 2025 Sep;645(8080):496-506. doi: 10.1038/s41586-025-09332-0. Epub 2025 Jul 30. PMID: 40739350; PMCID: PMC12422975.

    To help to introduce the topic of Cancer Evolution, Tumor Microenvironment (and Pancreatic Cancer), we are providing a series of recorded lectures from GSK. These lectures should be watched before the class. If you have any questions from these lectures, please, bring them to the in person class.